1 Abnormal Activity of Primary Somatosensory Cortex in Central Pain Syndrome 2 3
نویسندگان
چکیده
(1) Program in Neuroscience, (2) Department of Anatomy & Neurobiology, University of 5 Maryland School of Medicine, (3) Department of Endodontics, Prosthodontics and Operative 6 Dentistry, University of Maryland Baltimore College of Dental Surgery, (4) Department of 7 Physiology, University of Maryland School of Medicine. Baltimore, MD 21201. 8 9 10 Running head: Abnormal Activity of Somatosensory Cortex in Central Pain 11 12 Corresponding author: 13 Dr. Asaf Keller, Department of Anatomy & Neurobiology, University of Maryland School of 14 Medicine, 20 Penn Street, Baltimore, MD 21201 15 Tel: (410) 706-7307 16 Fax: (410) 706-2512 17 e-mail: kellerlab AT gmail.com 18 19 Articles in PresS. J Neurophysiol (July 21, 2010). doi:10.1152/jn.00161.2010
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Abnormal activity of primary somatosensory cortex in central pain syndrome.
Central pain syndrome (CPS) is a debilitating and chronic pain condition that results from a lesion or dysfunction in the CNS. The pathophysiological mechanisms underlying CPS are poorly understood. We recently demonstrated that CPS is associated with suppressed inputs from the inhibitory nucleus zona incerta to the posterior thalamus (PO). As a consequence, activity in PO is abnormally increas...
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